Synthesis of Poly(silyl ether-ester)s as Potential Drug Delivery Systems and Bioimaging Agents

Abstract: Poly(silyl ether-ester)s (PSEEs) are an exciting class of silicon-containing polymers that have their distinctive structure and properties. This study presents the synthesis and characterization of PSEE polymers, focusing on their potential application in the development of nanoparticles for drug delivery and bioimaging. The polymers were synthesized via ring-opening reduction polymerization of cyclic anhydrides with dihydrosilanes. The successful formation of PSEs was confirmed by distinct proton and carbon signals observed in NMR spectra, supported by molecular weight distributions obtained from GPC analysis. Key findings include the scalability of the synthesis process, with controlled variations in polymer and nanoparticle synthesis parameters influencing particle size and distribution.