Poly(silyl ether)-based Polymeric Nanoparticles as Potential Nanocarriers for Drug Delivery

Design and utilization of polymeric nanoparticles for use in the selective targeting of cells as well as controlled release of a drug is a major point of interest for many researchers in the field of cancer therapeutics. Poly(silyl ether) (PSE) based nanoparticles show promising use in this goal due to their ability to undergo the hydrolytic degradation of the Si-O-C bond present in PSE molecules, triggered by the increase of acidity similar to those seen in cancerous cells. In this study, we have prepared and characterized a series of PSEs from polyethylene glycol (PEG) base diols for the use of particle formation in order to monitor their ability to encapsulate and release a drug in an acidic environment similar to that of a cancerous cell.