Presentation: 2024 ND EPSCoR Annual conference
November 21, 2024, Alerus Center, Grand Forks, North Dakota
Poly(silyl ether)-based Polymeric Nanoparticles as Potential Nanocarriers for Drug Delivery
Zachary
Bailey
Doctoral Student
University of North Dakota
Co-authors: Vladimer Zotov, Doctoral Student, UND; Dr. Guodong Du, Professor, UND; Dr. Julia Zhao, Professor, UND
Session
Poster Session A
Poster #6
Design and utilization of polymeric nanoparticles for use in the selective targeting of cells as well as controlled release of a drug is a major point of interest for many researchers in the field of cancer therapeutics. Poly(silyl ether) (PSE) based nanoparticles show promising use in this goal due to their ability to undergo the hydrolytic degradation of the Si-O-C bond present in PSE molecules, triggered by the increase of acidity similar to those seen in cancerous cells. In this study, we have prepared and characterized a series of PSEs from polyethylene glycol (PEG) base diols for the use of particle formation in order to monitor their ability to encapsulate and release a drug in an acidic environment similar to that of a cancerous cell.
The ND-ACES NSF Track-1 cooperative agreement is a federal-state partnership to manage a comprehensive research development plan. ND EPSCoR manages the Track-1 award. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation. Current funding is provided by the State of North Dakota and NSF EPSCoR Research Infrastructure Improvement Program Track-1 (RII Track-1) Cooperative Agreement Award OIA #1946202.