Presentation: 2024 ND EPSCoR Annual conference
November 21, 2024, Alerus Center, Grand Forks, North Dakota
Engineering 3D In Vitro Bone Metastasis Models from Patient-Derived Prostate Cancer Subtypes
Quyen
Hoang
Doctoral Student
North Dakota State University
Co-authors: Preetham Ravi, PhD, Department of Civil and Environmental Engineering, NDSU; Sharad Jaswandkar, PhD, Department of Civil and Environmental Engineering, NDSU; Hanmant Gaikwad, Doctoral Grad Research Asst, Department of Civil and Environmental Engineering, NDSU; Shrinwanti Ghosh, Doctoral Grad Research Asst, Department of Biological Sciences, NDSU; Jiha Kim, Associate Professor, Department of Biological Sciences, NDSU; Parth Vyas, MD, Sanford Health; Dinesh R Katti, Professor, Department of Civil and Environmental Engineering, NDSU; Kalpana Katti, Distinguished Professor, Department of Civil and Environmental Engineering, NDSU
Session
Poster Session A
Poster #10
Bone metastasis in prostate cancer presents significant therapeutic resistance and contributes to increased mortality in advanced stages of the disease. This study focuses on developing personalized 3D in vitro bone metastasis models with patient-derived prostate cancer cell lines (CTR_PCA 3001, 3002, 3003, and 3004, obtained from Sanford Hospital). These models represent an advancement over our prior systems that employed commercial prostate cancer cell lines (PC3 and MDA PCa 2b) and offer a more accurate representation of the molecular and cellular behavior of patient-derived cancer cells within the bone microenvironment. These models, which incorporate various patient-derived prostate cancer subtypes, provide a valuable platform for investigating prostate cancer metastasis and have the potential to transform precision medicine approaches such as targeted therapy and drug discovery in oncology. Consequently, the development of these personalized 3D in vitro models considerably enhances the increasing role of precision and personalized medicine for cancer treatment.
The ND-ACES NSF Track-1 cooperative agreement is a federal-state partnership to manage a comprehensive research development plan. ND EPSCoR manages the Track-1 award. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation. Current funding is provided by the State of North Dakota and NSF EPSCoR Research Infrastructure Improvement Program Track-1 (RII Track-1) Cooperative Agreement Award OIA #1946202.