Presentation: 2025 ND EPSCoR Annual conference
October 21, 2025, NDSU Memorial Union, Fargo, North Dakota
Hyperbranched Poly(silyl ether)-based Polymeric Nanoparticles as Potential Nanocarriers for Cell Imaging
Zachary
Bailey
Doctoral Student
University of North Dakota
Co-authors: Vladimir V. Zotov (Student, UND), Julia Zhao (Professor, UND), Guodong Du (Professor, UND)
Session
Poster number: 125
Legacy Lounge
In our previous work we displayed the ability of linear poly(silyl ether) (PSE) based polymers to both be able to degrade in a cancer like environments as well as be formulated into nanoparticles to uptake a drug for potential use in cancer treatment. In this paper we hope to expand upon this concept and build on the uses of PSEs in cancer therapeutics. To achieve this, we have investigated the use of hyperbranched (HB) PSEs and their advantages over the linear analogues previously used. We further explore the utility of PSEs in cell imaging, examining their intrinsic fluorescence as well as their performance when paired with additional fluorescent compounds, either through uptake or direct conjugation.