Presentation: 2025 ND EPSCoR Annual conference
October 21, 2025, NDSU Memorial Union, Fargo, North Dakota
Antidiabetic and Antioxidant Potential of Plant Oxalis corniculata L.: In vitro and In silico Study
Quang Quy
Duong
Doctoral Student
North Dakota State University
Co-authors: Nguyen Thi Van Anh, PhD, University of Science and Technology of Hanoi (USTH), Vietnam Academy of Science and Technology, Hanoi, Vietnam, Nguyen Thanh Tung, PhD, Hanoi University of Pharmacy, Hanoi, Vietnam, Nguyen Anh Ngoc, PhD, University of Science and Technology of Hanoi (USTH), Vietnam Academy of Science and Technology, Hanoi, Vietnam, Nguyen Thi Minh Huyen, PhD, University of Science and Technology of Hanoi (USTH), Vietnam Academy of Science and Technology, Hanoi, Vietnam, Tue-Tam Ho, BPharm, Hanoi University of Pharmacy, Hanoi, Vietnam, Gerardo M. Casanola-Martin, PhD, Department of Coatings and Polymeric Materials, North Dakota State University, Fargo, ND, USA, Bakhtiyor Rasulev, PhD, Department of Coatings and Polymeric Materials, North Dakota State University, Fargo, ND, USA, Hai Pham-The, PhD, University of Science and Technology of Hanoi (USTH), Vietnam Academy of Science and Technology, Hanoi, Vietnam
Session
Poster number: 10
Ballroom
Medicinal plants provide a rich source of bioactive molecules with potential antidiabetic and antioxidant activities. The present work highlights the therapeutic promise of Oxalis corniculata L. aerial parts by assessing their ability to regulate carbohydrate metabolism and oxidative stress. Crude extracts and solvent fractions were evaluated using in vitro enzyme inhibition and antioxidant assays, combined with in silico network and molecular modeling analyses. Among all fractions, the ethyl acetate extract demonstrated the strongest inhibition of α-glucosidase and α-amylase, surpassing the reference drug acarbose. It also demonstrated considerable antioxidant activity in the DPPH and ABTS assays, which could be attributed to its high content of phenolic and flavonoid compounds. Predicted bioactive compounds were further characterized through network pharmacology analysis, which suggested diverse antidiabetic and antioxidant mechanisms. Specifically, compounds from O. corniculata may act on insulin resistance pathways, carbohydrate absorption and metabolism pathways, and signaling routes associated with diabetic complications, while also contributing to oxidative balance through the modulation of oxidoreductases and electron-transfer proteins. From computational part of this work, the Protein-Ligand Docking and Molecular Dynamics (MD) simulations were applied, which revealed a stable binding of compounds to enzyme targets, while quantum chemical calculations provided further insight into structural and antioxidant properties. Collectively, these findings support the use of plant O. corniculata aerial extracts as a source of natural compounds with antidiabetic and antioxidant potential, paving the way for future pharmaceutical development.