Presentation: 2025 ND EPSCoR Annual conference
October 21, 2025, NDSU Memorial Union, Fargo, North Dakota
Internal transfer kinetics of cargo in two-compartment carriers: A stochastic model
Md Faruk
Hossain
Doctoral Student
North Dakota State University
Co-authors: Guilherme Volpe Bossa 2, Sylvio May 1; 2 Institute of Mathematical and Physical Sciences, Universidad Austral de Chile, Valdivia 5090000, Chile, 1 North Dakota State University
Session
Poster number: 59
Ballroom
The two leaflets of a lipid vesicle are an example for a two-compartment carrier, where cargo such as lipids, sterols, or amphipathic drug molecules can partition between two reservoirs. We develop a stochastic model that describes the transfer kinetics of cargo among the two compartments of a carrier, starting from an arbitrary initial distribution. A Fokker-Planck equation is derived from a set of discrete kinetic equations and then solved analytically, leading to a detailed understanding of how molecular distributions evolve in time until reaching their equilibrium distributions.