The continued rise of multiple antibiotic-resistant bacteria is a major public health concern globally that requires urgent attention. The ESKAPE bacteria are of clinical importance because they have been implicated in hospital-acquired infections and are often resistant to multiple antibiotics. Nanoparticles are extremely small particles with at least one dimension less than 100 nanometers. They have shown promise as likely candidates in the search for alternatives to conventional antibiotics. However, many questions remain unanswered. Therefore, the overall aim of this study is to determine the antibacterial activity of triangular, spherical, and decahedral, green-synthesized silver nanoparticles (AgNPs) against ESKAPE bacteria. To achieve my aim, the antibacterial activity of various shapes of AgNPs synthesized was tested against ESKAPE bacteria using Kirby-Bauer disk diffusion method. Our results showed that the AgNPs have antibacterial activities against the tested bacteria, as measured by the diameter of inhibition (DOI). The average DOI are 10.50 mm, 10.26 mm and 9.46 mm for spherical, decahedral and triangular respectively. Therefore, spherical AgNPs were most effective against the majority of the ESKAPE bacteria. In the future, the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) will be determined. In conclusion, this study suggests that the AgNPs we have synthesized are a potential alternative solution to the antibiotic-resistant infections caused by ESKAPE bacteria.